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Ulipristal acetate: understanding its uses for EC and beyond

Downloadable resources

Uses for Ulipristal Acetate Beyond Emergency Contraception: Fact Sheet

UPA has shown significant promise for indications outside of EC, most notably treatment of uterine leiomyomas, but also ongoing contraception, prevention and treatment of breast cancer, and abnormal uterine bleeding. While UPA has extensive potential for use both within and beyond reproductive health, development is at a standstill due to concerns regarding its possible role in causing serious liver injury. The role of UPA in causing drug-induced liver injury (DILI) is not confirmed and pre-clinical studies during development did not demonstrate a concern that UPA causes DILI. Access to UPA is crucial not only for EC but for the treatment of many other gynecologic and non-gynecologic conditions. 

Ulipristal Acetate + Misoprostol: Background and Key Takeaways

A recent study that includes ulipristal acetate (UPA) as part of an abortion regimen may put a spotlight on EC pills, since UPA is currently marketed and indicated for EC use. The European Consortium for Emergency Contraception (ECEC) and the American Society for Emergency Contraception (ASEC) created this resource to provide background information about emergency contraceptive (EC) pills and medication abortion regimens. Publication of the new study creates renewed opportunities to educate about the importance of EC and its role in preventing pregnancy; dispel myths around EC pill use, safety, and mechanism of action; and uplift the importance of both EC and medication abortion while clarifying the differences. 

Ulipristal Acetate + Misoprostol: Summary 

This document summarizes key takeaways about new potential uses for ulipristal acetate (UPA), as a forthcoming study investigated use of UPA and misoprostol for early pregnancy termination. 

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©2025 by American Society for Emergency Contraception, under the fiscal sponsorship of Ipas.

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